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Main outcome measure Recurrent symptomatic VTE (independently and blindly adjudicated) over one year of follow-up.

Results Of 1213 women, 631 (51.3%) were classified as low risk and 591 discontinued oral anticoagulant treatment.

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Objective To prospectively validate the HERDOO2 rule (Hyperpigmentation, Edema, or Redness in either leg; D-dimer level ≥250 μg/L; Obesity with body mass index ≥30; or Older age, ≥65 years), which states that women with none or one of the criteria can safely discontinue anticoagulants after short term treatment. Setting 44 secondary or tertiary care centres in seven countries.

Participants Of 3155 consecutive eligible participants with a first unprovoked venous thromboembolism (VTE, proximal leg deep vein thrombosis or pulmonary embolism) who completed 5-12 months of short term anticoagulant treatment, 370 declined to participate, leaving 2785 enrolled participants. Interventions Women with none or one of the HERDOO2 criteria were classified as at low risk of recurrent VTE and discontinued anticoagulants (intervention arm), whereas anticoagulant management for high risk women (≥2 HERDOO2 criteria) and men was left to the discretion of the clinicians and patients (observation arm).

According to thirty academic and clinical educators who rated the match between the standardized patient assessment tool criteria and statements found in these documents, ninety-six percent (22/23) of the criteria agrees with at least one of the documents at statistically significant levels.

Thus, the project's investigators concluded that their assessment tool was valid and consistent with current practice expectations in Physical Therapy. Validating a standardized patient assessment tool using published professional standards.