The couple met while working together on the '90s cult TV show "Buffy," which starred Sarah Michelle Gellar as a high school cheerleader turned human foe of the undead.
Hannigan played Willow Rosenberg, Buffy's best friend, and Denisof entered the show in its third season as Wesley Wyndam-Pryce, Buffy's amusingly uptight would-be supervisor.
Aly and I have a lot of scenes together, spend a lot of time together, and she's always been there to listen to me and give me advice.
[She] saw me through hard times and good times," explained the actor, who split from girlfriend Michelle Williams in February last year.
Segel's kind words only made Hannigan cry further, and he comforted her by rubbing her shoulder.
Fans of “Buffy the Vampire Slayer” take note: Power couple Alyson Hannigan and Alexis Denisof have put their 4,200-square-foot home in Santa Monica, CA, up for rent.
Cobie Smulders tied the knot with her longterm love, Taran Killam, on Saturday at the Alisal Guest Ranch in Solvang, CA.
She wore a gorgeous dress from bridal designer Claire Pettibone.
But she added that she would "love to see any" of her cast members.While sharing what they'll miss most about each other, Alyson Hannigan (Lily Aldrin) cried over having to say goodbye to on-screen husband Jason Segel (Marshall Eriksen.) "Alyson, I mean, working together for ten years that's longer than some marriages in this town. "I'm on a daytime talk show crying, this isn't how it was supposed to go," joked the actress, who is married in real life to her former costar Alexis Denisof. " "If you don't cry you're a horrible person," costar Neil Patrick Harris joked to Segel.Say Jason, for example, what will you miss most about him? PHOTOS: Celebs crying "He's just such a wonderful guy . "Aly taught me a lot about how to be a man, I gotta say.Neil Patrick Harris and David Burtka also brought their little ones, Gideon and Harper.Joe Manganiello, who's appeared on HIMYM in the past and will reprise his role in the upcoming season, also attended the nuptials.